How 18th Century Boston Countered Vaccine Hesitancy

Lessons learned from a bygone time

Eric Weiner
9 min readSep 20, 2021
An artist’s satirical depiction of Dr. Edward Jenner administering smallpox vaccines

A deadly pathogen. Life upended. The economy crippled. Schools shuttered. A miracle vaccine developed but widespread mistrust of it. A populace divided. Voices raised. Violence threatened.

The year is not 2021 but 1721. The place is the Massachusetts Bay Colony. Vaccine hesitancy is not new. It is as old as vaccines themselves. The rancor dates back to a crude but effective form of immunization first practiced in Boston exactly three centuries ago. We have been here before, and there are lessons to learn from Boston’s vaccine wars.

Then, as now, the disease came from abroad. On April 22, 1721, a British merchant ship, the HMS Seahorse, docked at Boston Harbor. Within a day, one of the crew-members showed signs of smallpox and was, as was customary, quarantined. Nevertheless, the “speckled monster,” as smallpox was known, gained a foothold in the city, and with devastating result. It killed hundreds of Bostonians, nearly a tenth of the population, targeting the most vulnerable, the very young and the very old.

Then, as now, a six-foot rule was in place, though a very different kind from today’s. Any family with an infected member was told to erect a pole at least six feet in length and attach a red flag with the words “God…

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Eric Weiner
Eric Weiner

Written by Eric Weiner

Philosophical Traveler. Recovering Malcontent. Author of five books. My latest,:"BEN & ME: In Search of a Founder's Formula for a Long and Useful Life."

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